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KMID : 0361020020450100980
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Korean Journal of Otolaryngology - Head and Neck Surgery
2002 Volume.45 No. 10 p.980 ~ p.983
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Prognostic Significance of the Microvessel Density in Nasopharyngeal Carcinoma
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임상철/Sang Chul Lim
조재식/나애선/김판수/조형호/문석진/Jae Shik Cho/Ae Sun Na/Pan Su Kim/Hyong Ho Cho/Seok Jin Moon
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Abstract
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Background and Objectives: The nasopharyngeal cancer (NPC) of nasopharyngeal neoplasms is a rare disease with a relatively poor prognosis, because they tend to be diagnosed in the far advanced stage. Therefore, radiotherapy had been the
treatment
of choice. Angiogenesis is a crucial step in the tumor growth and progression. The authors attempted to investigate the prognostic value of the microvessel density in NPC.
Subjects and Method: We analyzed tumor tissues from 57 cases of paraffin block specimens which had been diagnosed with NPC and treated at Chonnam National University Hospital. The anti-human von Willebrand factor antibody was used to
determine
the microvessel density (MVD).
Results: The MVD was 48.5 in the early stage (stage Ⅰ and Ⅱ) and 51.2 in the advanced stage (stage Ⅲ and Ⅳ), which were not statistically significant (p=0.057). The MVD was 55.3 in type Ⅰ, 54.4 in type Ⅱ, and 41.8 in type Ⅲ, and there
were
no statistical significance between these values (p=0.36). The MVD was not statistically significant between T and N stages (p=0.26, 0.42). There was no significance between the MVD and the survival rates (p>0.05).
Conclusion: The results suggest that the MVD was not a prognostic significance in NPC.
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KEYWORD
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